Process Research, Development, and Optimization

• Process development of discovery routes/early development routes into robust manufacturing processes suitable for intended purpose
• Route scouting/selection for new scalable processes, including generation of innovative solutions to complex synthetic problems
• Process characterization as per ICH Q11 (Quality by Design)
• Technology transfer to manufacturing production
• Custom Synthesis
• Drug discovery & Preclinical development support
• CMC CTD Support

In-house Technology Platforms

• Asymmetric Ligands Platform Asymmetric catalytic innovation allows high-throughput library screening services for optimum ligand selection. Raybow has successfully used these chiral ligands in the process development of more than a dozen chiral intermediates or chiral APIs. These include several commercially marketed innovative Drug APIs.
• Fluorination Chemistry Platform SulfoxFluor reagent converts alcohols into alkyl fluorides with high efficiency, Carbonyl compounds can be converted to a difluoro-olefin and the difluoromethyl functional group can be introduced into the target compound efficiently, Trifluoromethyl functional group may be effectively introduced into the target compound.
• Flow Chemistry Platform Rich experience in flow chemistry process development for dozens of reaction types such as diazotization, Grignard, Curtius, nitration/nitrosation, oxidation, photoredox and rearrangement. Successfully completed tonnage scale-up production of Curtius rearrangement, cryogenic lithium reagent exchange and mono nitration reactions. Equipped with advanced experimental equipments in flow chemistry laboratory, including Corning flow reactor, British C-Tech lnnovation electrochemical reactor and Mettler online infrared instrument